Title : Everolimus with Reduced Calcineurin Inhibitor Exposure in Renal Transplantation.

Pub. Date : 2018 Jul

PMID : 29752413






2 Functional Relationships(s)
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1 Everolimus with Reduced Calcineurin Inhibitor Exposure in Renal Transplantation. Everolimus calcineurin binding protein 1 Homo sapiens
2 Background Everolimus permits reduced calcineurin inhibitor (CNI) exposure, but the efficacy and safety outcomes of this treatment after kidney transplant require confirmation.Methods In a multicenter noninferiority trial, we randomized 2037 de novo kidney transplant recipients to receive, in combination with induction therapy and corticosteroids, everolimus with reduced-exposure CNI (everolimus arm) or mycophenolic acid (MPA) with standard-exposure CNI (MPA arm). Everolimus calcineurin binding protein 1 Homo sapiens