Title : KRAS Activating Signaling Triggers Arteriovenous Malformations.

Pub. Date : 2018 Jul

PMID : 29748115






1 Functional Relationships(s)
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1 A study published in The New England Journal of Medicine reported that KRAS somatic mutations (p.Gly12Val/Asp) were identified in brain arteriovenous malformations of human subjects and endothelial cell-enriched cultures, which might specifically activate the MAPK (mitogen-activated protein kinase)-ERK (extracellular signal-regulated kinase) signaling pathway in brain endothelial cells. Aspartic Acid KRAS proto-oncogene, GTPase Homo sapiens