Title : Expression of genes associated with inflammation and iron metabolism in 3T3-L1 cells induced with macrophages-conditioned medium, glucose and iron.

Pub. Date : 2018 Aug

PMID : 29730778






3 Functional Relationships(s)
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1 Hepcidin (Hpc), a main iron metabolism regulator, is synthetized by an IL-6 stimuli, among others, in liver and adipose tissue, favoring an association between the inflammatory process and iron metabolism. Iron interleukin 6 Mus musculus
2 Hepcidin (Hpc), a main iron metabolism regulator, is synthetized by an IL-6 stimuli, among others, in liver and adipose tissue, favoring an association between the inflammatory process and iron metabolism. Iron interleukin 6 Mus musculus
3 Thus, we showed that combined high glucose/high Fe alone or with MCM may contribute to an increase on intracellular iron and inflammatory response in 3T3-L1 differentiated cells, by increased mRNA levels of IL-6, TNF-alpha, MCP-1, Hpc and reducing adiponectin levels, enhancing the inflammatory processes. Iron interleukin 6 Mus musculus