Pub. Date : 2018 Jun 1
PMID : 29718219
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Loss of this axis in Fxr:Shp:Car:Pxr quadruple knockouts blocked Cyp2b/Cyp2c gene induction, impaired bilirubin conjugation/elimination, and increased liver injury. | Bilirubin | nuclear receptor subfamily 1 group I member 3 | Homo sapiens |
| 2 | In conclusion, loss of FXR/SHP results in distinct molecular pathogenesis and CAR/PXR activation, which promotes Cyp2b/Cyp2c gene transcription and bilirubin clearance. | Bilirubin | nuclear receptor subfamily 1 group I member 3 | Homo sapiens |