PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29718219-8 2018 Loss of this axis in Fxr:Shp:Car:Pxr quadruple knockouts blocked Cyp2b/Cyp2c gene induction, impaired bilirubin conjugation/elimination, and increased liver injury. Bilirubin 102-111 nuclear receptor subfamily 1 group I member 3 Homo sapiens 29-32 29718219-10 2018 In conclusion, loss of FXR/SHP results in distinct molecular pathogenesis and CAR/PXR activation, which promotes Cyp2b/Cyp2c gene transcription and bilirubin clearance. Bilirubin 148-157 nuclear receptor subfamily 1 group I member 3 Homo sapiens 78-81