Title : The anti-epileptic drug lamotrigine inhibits the CYP17A1 lyase reaction in vitro.

Pub. Date : 2018 Oct 1

PMID : 29718108






1 Functional Relationships(s)
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1 This in silico study showed that LAM was able to bind directly to the heme iron in the active site of CYP17A1, but not CYP21A2, thus supporting the results of the in vitro studies. Iron cytochrome P450 family 17 subfamily A member 1 Homo sapiens