Title : The anti-epileptic drug lamotrigine inhibits the CYP17A1 lyase reaction in vitro.

Pub. Date : 2018 Oct 1

PMID : 29718108






2 Functional Relationships(s)
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1 The ability of LAM to bind to CYP17A1, CYP19A1, and CYP21A2 was investigated using docking and molecular dynamics simulations. Lamotrigine cytochrome P450 family 19 subfamily A member 1 Homo sapiens
2 The molecular dynamics simulations also suggested binding of LAM to the heme iron in the CYP19A1 active site. Lamotrigine cytochrome P450 family 19 subfamily A member 1 Homo sapiens