Title : The anti-epileptic drug lamotrigine inhibits the CYP17A1 lyase reaction in vitro.

Pub. Date : 2018 Oct 1

PMID : 29718108






1 Functional Relationships(s)
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1 All progestagens as well as 11-deoxycorticosterone and corticosterone increased 100-200% with increasing concentrations of LAM suggesting a selective inhibitory effect of LAM on CYP17A1, in particular on the lyase reaction. Desoxycorticosterone cytochrome P450 family 17 subfamily A member 1 Homo sapiens