Pub. Date : 2018
PMID : 29715320
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Deciphering the binding behavior of flavonoids to the cyclin dependent kinase 6/cyclin D complex. | Flavonoids | cyclin dependent kinase 6 | Homo sapiens |
| 2 | Flavonoids, a class of natural compounds with variable phenolic structures, have been found to possess anti-cancer activities by modulating different enzymes and receptors like CDK6. | Flavonoids | cyclin dependent kinase 6 | Homo sapiens |
| 3 | The binding efficiencies of flavonoids against the CDK6/cyclin D complex were mainly through the electrostatic (especially the H-bond force) and vdW interactions with residues ILE19, VAL27, ALA41, GLU61, PHE98, GLN103, ASP163 and LEU152. | Flavonoids | cyclin dependent kinase 6 | Homo sapiens |
| 4 | The order of binding affinities of these flavonoids toward the CDK6/cyclin D was M03 > M01 > M07 > M15 > M06 > M05 > M04. | Flavonoids | cyclin dependent kinase 6 | Homo sapiens |
| 5 | It is anticipated that the binding features of flavonoid inhibitors studied in the present work may provide valuable insights for the development of CDK6 inhibitors. | Flavonoids | cyclin dependent kinase 6 | Homo sapiens |