Title : Quantitative Analysis of Complex Drug-Drug Interactions between Cerivastatin and Metabolism/Transport Inhibitors Using Physiologically Based Pharmacokinetic Modeling.

Pub. Date : 2018 Jul

PMID : 29712725






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 CsA is an inhibitor of organic anion transporting polypeptide (OATP)1B1 and CYP3A4, and GEM and its glucuronide (GEM-glu) inhibit OATP1B1 and CYP2C8. Glucuronides solute carrier organic anion transporter family member 1B1 Homo sapiens