Pub. Date : 2018 Apr 29
PMID : 29710837
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mechanism of the Dual Activities of Human CYP17A1 and Binding to Anti-Prostate Cancer Drug Abiraterone Revealed by a Novel V366M Mutation Causing 17,20 Lyase Deficiency. | abiraterone | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 2 | The CYP17A1 gene regulates sex steroid biosynthesis in humans through 17α-hydroxylase/17,20 lyase activities and is a target of anti-prostate cancer drug abiraterone. | abiraterone | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 3 | Abiraterone could not bind and inhibit the 17α-hydroxylase activity of the CYP17A1-V366M mutant. | abiraterone | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 4 | The V366M mutant also explained the effectiveness of the anti-prostate cancer drug abiraterone as a potent inhibitor of CYP17A1 by binding tightly at the active site in the WT enzyme. | abiraterone | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |