Pub. Date : 2018
PMID : 29706998
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Melatonin Treatment Improves Insulin Resistance and Pigmentation in Obese Patients with Acanthosis Nigricans. | Melatonin | insulin | Homo sapiens |
| 2 | Objective: This study aimed to determine the effects of melatonin on insulin resistance in obese patients with acanthosis nigricans (AN). | Melatonin | insulin | Homo sapiens |
| 3 | Results: After 12 weeks of treatment with melatonin (3 mg/day), homeostasis model assessment insulin resistance index (HOMA-IR) (8.99 +- 5.10 versus 7.77 +- 5.21, p < 0.05) and fasting insulin (37.09 5 +- 20.26 muU/ml versus 32.10 +- 20.29 muU/ml, p < 0.05) were significantly decreased. | Melatonin | insulin | Homo sapiens |
| 4 | Results: After 12 weeks of treatment with melatonin (3 mg/day), homeostasis model assessment insulin resistance index (HOMA-IR) (8.99 +- 5.10 versus 7.77 +- 5.21, p < 0.05) and fasting insulin (37.09 5 +- 20.26 muU/ml versus 32.10 +- 20.29 muU/ml, p < 0.05) were significantly decreased. | Melatonin | insulin | Homo sapiens |
| 5 | Conclusions: It was concluded that melatonin could improve cutaneous symptoms in obese patients with acanthosis nigricans by improving insulin sensitivity and inflammatory status. | Melatonin | insulin | Homo sapiens |