Title : Celecoxib use and circulating oxylipins in a colon polyp prevention trial.

Pub. Date : 2018

PMID : 29698447






2 Functional Relationships(s)
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1 Individual CYP450- and LOX- but not COX-derived metabolites were higher with celecoxib than placebo (P<0.05) and differences were greater among non-aspirin users. Celecoxib cytochrome P450 family 4 subfamily F member 3 Homo sapiens
2 20-HETE, a prohypertensive androgen-sensitive CYP450 metabolite was higher with celecoxib absent aspirin and was positively associated with SBP in men (P = 0.040) but not women. Celecoxib cytochrome P450 family 4 subfamily F member 3 Homo sapiens