Title : P2Y12 antagonist ticagrelor inhibits the release of procoagulant extracellular vesicles from activated platelets.

Pub. Date : 2019

PMID : 29671861






2 Functional Relationships(s)
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1 Adenosine diphosphate (ADP) receptors P2Y1 and P2Y12 both play a role in platelet activation, The present hypothesis herein is that the inhibition of these receptors may affect the release of PEVs. Adenosine Diphosphate purinergic receptor P2Y12 Homo sapiens
2 RESULTS: ADP-induced aggregation (57 +- 13 area under curve {AUC] units) was inhibited 73% by the P2Y1 antagonist, 86% by the P2Y12 antagonist, and 95% when combined (p < 0.001 for all). Adenosine Diphosphate purinergic receptor P2Y12 Homo sapiens