Title : Cyproheptadine Regulates Pyramidal Neuron Excitability in Mouse Medial Prefrontal Cortex.

Pub. Date : 2018 Oct

PMID : 29671217






3 Functional Relationships(s)
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1 Cyproheptadine (CPH), a first-generation antihistamine, enhances the delayed rectifier outward K+ current (IK) in mouse cortical neurons through a sigma-1 receptor-mediated protein kinase A pathway. Cyproheptadine sigma non-opioid intracellular receptor 1 Mus musculus
2 Cyproheptadine (CPH), a first-generation antihistamine, enhances the delayed rectifier outward K+ current (IK) in mouse cortical neurons through a sigma-1 receptor-mediated protein kinase A pathway. Cyproheptadine sigma non-opioid intracellular receptor 1 Mus musculus
3 This effect of CPH was mimicked by a sigma-1 receptor agonist and eliminated by an antagonist. Cyproheptadine sigma non-opioid intracellular receptor 1 Mus musculus