Protein Name sigma non-opioid intracellular receptor 1
Organism Mus musculus
Gene ID 18391
Gene Symbol

Sigmar1

UniProt O55242 (SGMR1_MOUSE), I4DCY6 (I4DCY6_MOUSE), B7ZJH8 (B7ZJH8_MOUSE), B7ZJH7 (B7ZJH7_MOUSE), A2AMS0 (A2AMS0_MOUSE), B7ZJH9 (B7ZJH9_MOUSE), B7ZJH6 (B7ZJH6_MOUSE)
Relationships Total Number of functionally related compound(s) : 248
Total Number of Articles : 315
Description

sigma non-opioid intracellular receptor 1

Gene Summary

This gene encodes a transmembrane protein located in the endoplasmic reticulum. The encoded protein is a receptor that binds several endogenous ligands, including N,N-dimethyltryptamine, progesterone and pregnenolone and a variety of of non-opiate compounds. The encoded protein plays a role in regulating the activity of ion channels, acting as a chaperone and protecting cells from oxidative stress. In humans, this receptor has been associated with Alzheimer's and Parkinson's diseases, stroke and numerous disease conditions such as depression, pain and addiction. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Nov 2013]

synonyms
  • sigma non-opioid intracellular receptor 1
  • opioid receptor, sigma 1
  • sigma 1 receptor variant SR-1D
Click to show/hide the synonyms
Properties