Title : Synthetic biology-based cellular biomedical tattoo for detection of hypercalcemia associated with cancer.

Pub. Date : 2018 Apr 18

PMID : 29669854






2 Functional Relationships(s)
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1 For this purpose, we designed cells containing an ectopically expressed calcium-sensing receptor rewired to a synthetic signaling cascade that activates expression of transgenic tyrosinase, which produces melanin in response to persistently increased blood Ca2+ We confirmed that the melanin-generated color change produced by this biomedical tattoo could be detected with the naked eye and optically quantified. Melanins tyrosinase Mus musculus
2 For this purpose, we designed cells containing an ectopically expressed calcium-sensing receptor rewired to a synthetic signaling cascade that activates expression of transgenic tyrosinase, which produces melanin in response to persistently increased blood Ca2+ We confirmed that the melanin-generated color change produced by this biomedical tattoo could be detected with the naked eye and optically quantified. Melanins tyrosinase Mus musculus