Title : A Novel Tetrasubstituted Imidazole as a Prototype for the Development of Anti-inflammatory Drugs.

Pub. Date : 2018 Aug

PMID : 29656318






1 Functional Relationships(s)
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1 Of the eight imidazoles tested, methyl 1-allyl-2-(4-fluorophenyl)-5-phenyl-1H-imidazole-4-acetate (8) inhibited nitric oxide metabolites and pro-inflammatory cytokine (TNF-alpha, IL-6, and IL-1beta) secretion in J774 macrophages stimulated with LPS. Nitric Oxide interleukin 6 Mus musculus