Title : Inhibition of NLRP9b attenuates acute lung injury through suppressing inflammation, apoptosis and oxidative stress in murine and cell models.

Pub. Date : 2018 Sep 5

PMID : 29655793






1 Functional Relationships(s)
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1 Pre-treatment of MLE-12 cells with ROS scavenger of N-acetylcysteine (NAC) remarkably decreased lipopolysaccharide (LPS)- and rMuNLRP9-induced production of ROS, and the secretion of inflammatory cytokines or chemokine, as well as the activity of IkappaBalpha/NF-kappaB, ASC/Casapse-1 and Caspase-3/PARP signaling pathways. Reactive Oxygen Species nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus