Title : [Topoisomerase inhibitor upregulates MICA/B expression in breast cancer cells through ATM/ATR and NF-κB pathway].

Pub. Date : 2018 Apr 18

PMID : 29643533






2 Functional Relationships(s)
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1 RESULTS: Three topoisomerase inhibitors etoposide, camptothecin and doxorubicine upregulated MICA and MICB mRNA expressions in breast cancer cell MCF-7. Etoposide MHC class I polypeptide-related sequence B Homo sapiens
2 MICB mRNA expression also increased slightly in another breast cancer cell SK-BR-3 treated by topoisomerase II inhibitors etoposide and camptothecin (P<0.05). Etoposide MHC class I polypeptide-related sequence B Homo sapiens