Title : Dopamine inhibition of proopiomelanocortin gene expression in the intermediate lobe of the pituitary. Interactions with corticotropin-releasing factor and the beta-adrenergic receptors and the adenylate cyclase system.

Pub. Date : 1988 Feb

PMID : 2963967






2 Functional Relationships(s)
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1 Activating adenylate cyclase with forskolin (1 microM) or treatment with 8-bromocyclic adenosine monophosphate (1 mM) doubled POMC messenger RNA levels, and, when tested against these stimuli, bromocriptine still produced a 30% inhibition of POMC gene expression. 8-Bromo Cyclic Adenosine Monophosphate proopiomelanocortin Rattus norvegicus
2 Activating adenylate cyclase with forskolin (1 microM) or treatment with 8-bromocyclic adenosine monophosphate (1 mM) doubled POMC messenger RNA levels, and, when tested against these stimuli, bromocriptine still produced a 30% inhibition of POMC gene expression. 8-Bromo Cyclic Adenosine Monophosphate proopiomelanocortin Rattus norvegicus