Title : Low-dose tributyltin exposure induces an oxidative stress-triggered JNK-related pancreatic β-cell apoptosis and a reversible hypoinsulinemic hyperglycemia in mice.

Pub. Date : 2018 Apr 10

PMID : 29636531






4 Functional Relationships(s)
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1 Low-dose tributyltin exposure induces an oxidative stress-triggered JNK-related pancreatic beta-cell apoptosis and a reversible hypoinsulinemic hyperglycemia in mice. tributyltin mitogen-activated protein kinase 8 Mus musculus
2 Submicromolar-concentration of TBT significantly induced beta-cell cytotoxicity and apoptosis, which were accompanied by poly (ADP-ribose) polymerase cleavage and mitogen-activated protein kinases-JNK and ERK1/2 phosphorylation. tributyltin mitogen-activated protein kinase 8 Mus musculus
3 TBT-induced beta-cell cytotoxicity and apoptosis were significantly prevented by antioxidant N-acetylcysteine (NAC) and JNK inhibitor SP600125, but not ERK1/2 inhibitor PD98059 and p38 inhibitor SB203580. tributyltin mitogen-activated protein kinase 8 Mus musculus
4 Both NAC and SP600125 inhibited JNK phosphorylation and reduced cell viability in TBT-treated beta-cells. tributyltin mitogen-activated protein kinase 8 Mus musculus