Title : Targeting NAD+/PARP DNA Repair Pathway as a Novel Therapeutic Approach to SDHB-Mutated Cluster I Pheochromocytoma and Paraganglioma.

Pub. Date : 2018 Jul 15

PMID : 29636359






1 Functional Relationships(s)
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1 Alteration in mitochondrial function resulted in strengthened NAD+ metabolism, here considered as a key mechanism of chemoresistance, particularly, of succinate dehydrogenase subunit B (SDHB)-mutated cluster I PCPGs via the PARP1/BER DNA repair pathway. NAD poly (ADP-ribose) polymerase family, member 1 Mus musculus