Title : Chronic treatment with L-5-hydroxytryptophan prevents the development of DOCA-salt-induced hypertension in rats.

Pub. Date : 1987 Oct

PMID : 2963066






3 Functional Relationships(s)
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1 The exaggerated dipsogenic response of DOCA-treated rats to administration of angiotensin II (AII, 50 and 100 micrograms/kg, s.c.) was also reduced by treatment with L-5-HTP (4.2 and 8.4 mg/day). 5-Hydroxytryptophan angiotensinogen Rattus norvegicus
2 The exaggerated dipsogenic response of DOCA-treated rats to administration of angiotensin II (AII, 50 and 100 micrograms/kg, s.c.) was also reduced by treatment with L-5-HTP (4.2 and 8.4 mg/day). 5-Hydroxytryptophan angiotensinogen Rattus norvegicus
3 The specific binding of AII to its receptors in membranes from the diencephalon of the brain was increased significantly above control level by chronic treatment with DOCA, but was returned to control level by concomitant treatment with L-5-HTP. 5-Hydroxytryptophan angiotensinogen Rattus norvegicus