Title : Inhibition of Astrocyte Connexin 43 Channels Facilitates the Differentiation of Oligodendrocyte Precursor Cells Under Hypoxic Conditions In Vitro.

Pub. Date : 2018 Apr

PMID : 29623602






2 Functional Relationships(s)
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1 Application of astrocytic Cx43 blockers attenuated astrocyte activation, suppressed Cx43 hemichannel uptake activity and glutamate release induced by hypoxia, as well as improved OPC differentiation. Glutamic Acid gap junction protein alpha 1 Homo sapiens
2 In conclusion, these findings suggested that astrocytic Cx43 hemichannel inhibition could potentially improve OPC maturation by attenuating AMPAR-mediated glutamate signaling. Glutamic Acid gap junction protein alpha 1 Homo sapiens