Title : Contribution of Factor VIII A2 Domain Residues 400-409 to a Factor X-Interactive Site in the Factor Xase Complex.

Pub. Date : 2018 May

PMID : 29614522






1 Functional Relationships(s)
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1 SDS-PAGE demonstrated that the purified inhibitor IgG recognizing residues 373-562 blocked FXa cleavage at Arg372 in FVIII, and surface-plasmon resonance (SPR)-based assays showed that intact A2 subunit directly bound to FX (Kd; 63 nM). Sodium Dodecyl Sulfate coagulation factor VIII Homo sapiens