Protein Name coagulation factor VIII
Organism Homo sapiens
Gene ID 2157
Gene Symbol


UniProt P00451 (FA8_HUMAN)
Relationships Total Number of functionally related compound(s) : 405
Total Number of Articles : 621

coagulation factor VIII

Gene Summary

This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq, Jul 2008]

  • coagulation factor VIII
  • antihemophilic factor
  • coagulation factor VIII A1 domain
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