Title : Activation of the monocytic α7 nicotinic acetylcholine receptor modulates oxidative stress and inflammation-associated development of coronary artery spasm via a p38 MAP-kinase signaling-dependent pathway.

Pub. Date : 2018 May 20

PMID : 29609021






2 Functional Relationships(s)
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1 We also demonstrated that compared with the IL-6 expression elicited by CRP alone (p = 0.0489), the CRP-induced rise in monocytic IL-6 mRNA and protein expression in the presence of nicotine (p = 0.0002), is mediated by alpha7-nAChR activation and the deregulation of the human p38 mitogen-activated protein kinases (MAPK) signaling pathway. Nicotine interleukin 6 Homo sapiens
2 CONCLUSIONS: Our data demonstrate that the elevated monocytic IL-6 and alpha7-nAChR mRNA and protein expression levels are associated with the interaction between nicotine and CRP positively modulates CAS development. Nicotine interleukin 6 Homo sapiens