Pub. Date : 2018 Jun
PMID : 29604589
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Oncosis-like cell death is induced by berberine through ERK1/2-mediated impairment of mitochondrial aerobic respiration in gliomas. | Berberine | mitogen-activated protein kinase 3 | Homo sapiens |
| 2 | We also found that berberine induced autophagy as a protective effect and decreased the oxygen consumption rate (OCR), which could inhibit mitochondrial aerobic respiration by repressing phosphorylated extracellular regulated protein kinases (p-ERK1/2). | Berberine | mitogen-activated protein kinase 3 | Homo sapiens |
| 3 | Furthermore, the down-regulation of mitochondrial p-ERK1/2 by berberine inhibited aerobic respiration and led to glycolysis, an inefficient energy production pathway. | Berberine | mitogen-activated protein kinase 3 | Homo sapiens |
| 4 | In addition, berberine reduced tumor growth and inhibited Ki-67 and p-ERK1/2 expression in vivo. | Berberine | mitogen-activated protein kinase 3 | Homo sapiens |
| 5 | The results demonstrate that berberine, which represses aerobic oxidation in mitochondria and decreases their energy production efficiency, decreases metabolic activity by reducing ERK1/2 activity. | Berberine | mitogen-activated protein kinase 3 | Homo sapiens |