Title : 2',3-dihydroxy-5-methoxybiphenyl suppresses fMLP-induced superoxide anion production and cathepsin G release by targeting the β-subunit of G-protein in human neutrophils.

Pub. Date : 2018 Jun 15

PMID : 29601810






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Furthermore, RIR-2 attenuated fMLP-induced intracellular calcium mobilization by inhibiting the interaction between Gbeta-protein with PLCbeta2. Calcium formyl peptide receptor 1 Homo sapiens
2 RIR-2 specifically modulates fMLP-mediated neutrophil superoxide anion production and cathepsin G release by inhibiting the interaction between Gbeta-protein with downstream signaling which subsequently interferes with the activation of intracellular calcium, PLCgamma2, AKT, p38, PKC, ERK, p47ph x and p40phox. Calcium formyl peptide receptor 1 Homo sapiens