Title : Identification of multi-target inhibitors of leukotriene and prostaglandin E2 biosynthesis by structural tuning of the FLAP inhibitor BRP-7.

Pub. Date : 2018 Apr 25

PMID : 29597170

1 Functional Relationships(s)
Compound Name
Protein Name
1 Here, we report on novel multi-target inhibitors that potently and dually interfere with 5-lipoxygenase-activating protein (FLAP) and microsomal prostaglandin E2 synthase (mPGES)-1 in LT and PGE2 biosynthesis, based on the previously identified selective FLAP inhibitor BRP-7 (8, IC50 = 0.31 muM). Dinoprostone prostaglandin E synthase Homo sapiens