Title : Identification of multi-target inhibitors of leukotriene and prostaglandin E2 biosynthesis by structural tuning of the FLAP inhibitor BRP-7.

Pub. Date : 2018 Apr 25

PMID : 29597170






1 Functional Relationships(s)
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Protein Name
Organism
1 C (5)-substitution of the benzimidazole ring of BRP-7 by carboxylic acid and its bioisosteres provided compounds, exemplified by 57 that potently suppress LT formation (IC50 = 0.05 muM) by targeting FLAP along with inhibition of mPGES-1 (IC50 = 0.42 muM). benzimidazole prostaglandin E synthase Mus musculus