Pub. Date : 2018 Aug 30
PMID : 29596995
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Applying ketamine to alleviate the PTSD-like effects by regulating the HCN1-related BDNF. | Ketamine | brain-derived neurotrophic factor | Rattus norvegicus |
| 2 | The hyperpolarization-activated cyclic nucleotide-gated channel 1(HCN1) could be inhibited by the ketamine, a drug to alleviate depression and anxiety, and regulated the BDNF expression, however, the effects of ketamine in alleviating PTSD symptoms by regulating the HCN1-related BDNF have been poorly perceived. | Ketamine | brain-derived neurotrophic factor | Rattus norvegicus |
| 3 | The hyperpolarization-activated cyclic nucleotide-gated channel 1(HCN1) could be inhibited by the ketamine, a drug to alleviate depression and anxiety, and regulated the BDNF expression, however, the effects of ketamine in alleviating PTSD symptoms by regulating the HCN1-related BDNF have been poorly perceived. | Ketamine | brain-derived neurotrophic factor | Rattus norvegicus |
| 4 | The hyperpolarization-activated cyclic nucleotide-gated channel 1(HCN1) could be inhibited by the ketamine, a drug to alleviate depression and anxiety, and regulated the BDNF expression, however, the effects of ketamine in alleviating PTSD symptoms by regulating the HCN1-related BDNF have been poorly perceived. | Ketamine | brain-derived neurotrophic factor | Rattus norvegicus |
| 5 | Meanwhile, ketamine with dose of 15 mg/kg could increase the BDNF protein level, while down-regulate the expression of the HCN1. | Ketamine | brain-derived neurotrophic factor | Rattus norvegicus |
| 6 | CONCLUSION: Ketamine affects the HCN1-related BDNF signaling pathways to alleviate PTSD-like effects in rat. | Ketamine | brain-derived neurotrophic factor | Rattus norvegicus |