Title : Identifying off-target effects of etomoxir reveals that carnitine palmitoyltransferase I is essential for cancer cell proliferation independent of β-oxidation.

Pub. Date : 2018 Mar

PMID : 29596410






2 Functional Relationships(s)
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1 Here we show that when FAO was reduced approximately 90% by pharmacological inhibition of carnitine palmitoyltransferase I (CPT1) with low concentrations of etomoxir, the proliferation rate of various cancer cells was unaffected. etomoxir carnitine palmitoyltransferase 1A Homo sapiens
2 Moreover, CPT1 knockdowns had altered mitochondrial morphology and impaired mitochondrial coupling, whereas cells in which CPT1 had been approximately 90% inhibited by etomoxir did not. etomoxir carnitine palmitoyltransferase 1A Homo sapiens