Pub. Date : 2018 Mar 27
PMID : 29588478
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Lenalidomide, a drug that induces proteosomal degradation of IKZF1, also decreases pDC numbers in vivo, and reduces the ratio of pDC/cDC1 differentiated from progenitor cells in vitro in a dose-dependent manner. | Lenalidomide | IKAROS family zinc finger 1 | Homo sapiens |
| 2 | These results indicate that human DC development and function are regulated by IKZF1, providing further insights into the consequences of IKZF1 mutation on immune function and the mechanism of immunomodulation by lenalidomide. | Lenalidomide | IKAROS family zinc finger 1 | Homo sapiens |