Title : IRF9 and unphosphorylated STAT2 cooperate with NF-κB to drive IL6 expression.

Pub. Date : 2018 Apr 10

PMID : 29581268






2 Functional Relationships(s)
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1 In response to IFNbeta, the IL6 gene is activated, modestly at early times by ISGF3 (IRF9 plus tyrosine-phosphorylated STATs 1 and 2), and strongly at late times by U-ISGF3 (IRF9 plus U-STATs 1 and 2, lacking tyrosine phosphorylation). Tyrosine interleukin 6 Homo sapiens
2 In response to IFNbeta, the IL6 gene is activated, modestly at early times by ISGF3 (IRF9 plus tyrosine-phosphorylated STATs 1 and 2), and strongly at late times by U-ISGF3 (IRF9 plus U-STATs 1 and 2, lacking tyrosine phosphorylation). Tyrosine interleukin 6 Homo sapiens