Pub. Date : 2018 Jun
PMID : 29574692
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | P2Y12 receptor modulation of ADP-evoked intracellular Ca2+ signalling in THP-1 human monocytic cells. | Adenosine Diphosphate | purinergic receptor P2Y12 | Homo sapiens |
| 2 | BACKGROUND AND PURPOSE: The Gi -coupled, ADP-activated P2Y12 receptor is well characterized as playing a key role in platelet activation via crosstalk with the P2Y1 receptor in ADP-evoked intracellular Ca2+ responses. | Adenosine Diphosphate | purinergic receptor P2Y12 | Homo sapiens |
| 3 | However, there is limited knowledge on the role of P2Y12 receptors in ADP-evoked Ca2+ responses in other blood cells. | Adenosine Diphosphate | purinergic receptor P2Y12 | Homo sapiens |
| 4 | Here, we investigated the role of P2Y12 receptor activation in the modulation of ADP-evoked Ca2+ responses in human THP-1 monocytic cells. | Adenosine Diphosphate | purinergic receptor P2Y12 | Homo sapiens |
| 5 | ADP-evoked responses were attenuated either with pertussis toxin treatment, or P2Y12 receptor inhibition with two chemically distinct antagonists (ticagrelor, IC50 5.3 muM; PSB-0739, IC50 5.6 muM). | Adenosine Diphosphate | purinergic receptor P2Y12 | Homo sapiens |
| 6 | ADP-evoked responses were suppressed following siRNA-mediated P2Y12 gene knockdown. | Adenosine Diphosphate | purinergic receptor P2Y12 | Homo sapiens |