Pub. Date : 2018 Jun 29
PMID : 29572389
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nicotine enhances mesangial cell proliferation and fibronectin production in high glucose milieu via activation of Wnt/beta-catenin pathway. | Nicotine | catenin beta 1 | Homo sapiens |
| 2 | In the present study, we examined the involvement of Wnt/beta-catenin pathway in nicotine-mediated mesangial cell growth in high glucose milieu. | Nicotine | catenin beta 1 | Homo sapiens |
| 3 | Similarly, nicotine increased the expression of Wnts, beta-catenin, and fibronectin in normal glucose medium, but further increased mesangial cell expression of these proteins in high glucose milieu. | Nicotine | catenin beta 1 | Homo sapiens |
| 4 | Pharmacological inhibition or genetic knockdown of beta-catenin activity or expression with specific inhibitor FH535 or siRNA significantly impaired the nicotine/glucose-stimulated cell proliferation and fibronectin production. | Nicotine | catenin beta 1 | Homo sapiens |
| 5 | We conclude that nicotine may enhance renal mesangial cell proliferation and fibronectin production under high glucose milieus partly through activating Wnt/beta-catenin pathway. | Nicotine | catenin beta 1 | Homo sapiens |