Title : Striatal phosphodiesterase 10A availability is altered secondary to chronic changes in dopamine neurotransmission.

Pub. Date : 2017

PMID : 29564380






2 Functional Relationships(s)
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1 Treatment with the selective D2 antagonist SCH23390 (1 mg/kg) and D-amphetamine decreased PDE10A binding (-22 %, p = 0.03). Dextroamphetamine phosphodiesterase 10A Homo sapiens
2 Conclusions: Repeated D-amphetamine treatment significantly increased PDE10A binding, which is not observed upon selective D1 receptor blocking. Dextroamphetamine phosphodiesterase 10A Homo sapiens