Title : Oral Bruton tyrosine kinase inhibitors selectively block atherosclerotic plaque-triggered thrombus formation in humans.

Pub. Date : 2018 Jun 14

PMID : 29559479






1 Functional Relationships(s)
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1 We found that ibrutinib and the novel Btk inhibitors acalabrutinib and ONO/GS-4059 block GPVI-dependent static platelet aggregation in blood exposed to human plaque homogenate and collagen but not to ADP or arachidonic acid. Arachidonic Acid glycoprotein VI platelet Homo sapiens