Title : An optically controlled probe identifies lipid-gating fenestrations within the TRPC3 channel.

Pub. Date : 2018 Apr

PMID : 29556099






4 Functional Relationships(s)
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1 Transient receptor potential canonical (TRPC) channels TRPC3, TRPC6 and TRPC7 are able to sense the lipid messenger diacylglycerol (DAG). Diglycerides transient receptor potential cation channel subfamily C member 3 Homo sapiens
2 Transient receptor potential canonical (TRPC) channels TRPC3, TRPC6 and TRPC7 are able to sense the lipid messenger diacylglycerol (DAG). Diglycerides transient receptor potential cation channel subfamily C member 3 Homo sapiens
3 To gain insights into the lipid-sensing principle, we generated a DAG photoswitch, OptoDArG, that enabled efficient control of TRPC3 by light. Diglycerides transient receptor potential cation channel subfamily C member 3 Homo sapiens
4 Exchange of G652 with larger residues altered the ability of TRPC3 to discriminate between different DAG molecules. Diglycerides transient receptor potential cation channel subfamily C member 3 Homo sapiens