Title : Protease-activated receptor 1 is implicated in irritable bowel syndrome mediators-induced signaling to thoracic human sensory neurons.

Pub. Date : 2018 Jul

PMID : 29554016






2 Functional Relationships(s)
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1 Calcium signaling in response to PAR agonist peptides (PAR-AP), their inactive peptides (PAR-IP), thrombin (10 U/mL), supernatants from colonic biopsies of patients with IBS, or healthy controls, with or without PAR1 or PAR4 antagonist were studied in cultured human DRG neurons. Calcium coagulation factor II, thrombin Homo sapiens
2 Thrombin increased calcium flux, which was inhibited by a PAR1 antagonist and increased by a PAR4 antagonist. Calcium coagulation factor II, thrombin Homo sapiens