Pub. Date : 2018 Jun
PMID : 29550635
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Participation of the IKK-alpha/beta complex in the inhibition of the TNF-alpha/NF-kappaB pathway by glycine: Possible involvement of a membrane receptor specific to adipocytes. | Glycine | tumor necrosis factor | Homo sapiens |
| 2 | Glycine modulates inflammatory processes mediated by macrophages and adipocytes through decreasing the secretion of TNF-alpha, IL-6, and leptin, while increasing adiponectin. | Glycine | tumor necrosis factor | Homo sapiens |
| 3 | However, glycine upstream mainly influences the IkappaB kinase (IKK) complex, a multi-protein kinase complex considered a critical point in regulation of the NF-kappaB pathway; whether that is responsible for the TNF-alpha-induced phosphorylation of IkB has not been explored. | Glycine | tumor necrosis factor | Homo sapiens |
| 4 | In this research, participation of the IKK-alpha/beta complex in the inhibition of the TNF-alpha/NF-kappaB pathway by glycine was evaluated and associated with the synthesis and secretion of inflammatory cytokines in 3T3-L1 adipocytes. | Glycine | tumor necrosis factor | Homo sapiens |
| 5 | Glycine decreased the IKK-alpha/beta complex and the phosphorylation of NF-kappaB, diminishing the expression and secretion of IL-6 and TNF-alpha, but increasing that of adiponectin. | Glycine | tumor necrosis factor | Homo sapiens |
| 6 | In conclusion, the reduction of TNF-alpha and IL-6 and suppression of the TNF-alpha/NF-kappaB pathway by glycine may be explained in part by inhibition of the IKK-alpha/beta complex, with a possible participation of GlyR in 3T3-L1 adipocytes. | Glycine | tumor necrosis factor | Homo sapiens |