PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29550635-0	2018	Participation of the IKK-alpha/beta complex in the inhibition of the TNF-alpha/NF-kappaB pathway by glycine: Possible involvement of a membrane receptor specific to adipocytes.	Glycine	100-107	tumor necrosis factor	Homo sapiens	69-78	
29550635-1	2018	Glycine modulates inflammatory processes mediated by macrophages and adipocytes through decreasing the secretion of TNF-alpha, IL-6, and leptin, while increasing adiponectin.	Glycine	0-7	tumor necrosis factor	Homo sapiens	116-125	
29550635-3	2018	However, glycine upstream mainly influences the IkappaB kinase (IKK) complex, a multi-protein kinase complex considered a critical point in regulation of the NF-kappaB pathway; whether that is responsible for the TNF-alpha-induced phosphorylation of IkB has not been explored.	Glycine	9-16	tumor necrosis factor	Homo sapiens	213-222	
29550635-5	2018	In this research, participation of the IKK-alpha/beta complex in the inhibition of the TNF-alpha/NF-kappaB pathway by glycine was evaluated and associated with the synthesis and secretion of inflammatory cytokines in 3T3-L1 adipocytes.	Glycine	118-125	tumor necrosis factor	Homo sapiens	87-96	
29550635-7	2018	Glycine decreased the IKK-alpha/beta complex and the phosphorylation of NF-kappaB, diminishing the expression and secretion of IL-6 and TNF-alpha, but increasing that of adiponectin.	Glycine	0-7	tumor necrosis factor	Homo sapiens	136-145	
29550635-10	2018	In conclusion, the reduction of TNF-alpha and IL-6 and suppression of the TNF-alpha/NF-kappaB pathway by glycine may be explained in part by inhibition of the IKK-alpha/beta complex, with a possible participation of GlyR in 3T3-L1 adipocytes.	Glycine	105-112	tumor necrosis factor	Homo sapiens	74-83