Title : Local Anesthetic Drug Inhibits Growth and Survival in Chronic Myeloid Leukemia Through Suppressing PI3K/Akt/mTOR.

Pub. Date : 2018 Mar

PMID : 29549929






2 Functional Relationships(s)
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1 Importantly, combination of ropivacaine with imatinib or dasatinib (Bcr-Abl tyrosine kinase inhibitors) is significantly more effective in targeting CML cell lines as well as blast phase-CML CD34 cells than imatinib or dasatinib alone. Dasatinib ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens
2 Importantly, combination of ropivacaine with imatinib or dasatinib (Bcr-Abl tyrosine kinase inhibitors) is significantly more effective in targeting CML cell lines as well as blast phase-CML CD34 cells than imatinib or dasatinib alone. Dasatinib ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens