Pub. Date : 2018 Jul
PMID : 29549391
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | RATIONALE: Recent preclinical data has implicated the alpha7 nicotinic acetylcholine receptor (nAChR) as a target in modulating nicotine reward. | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 2 | However, the role of the channel properties of the alpha7 nAChR in nicotine withdrawal is unknown. | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 3 | OBJECTIVES: This study aimed to investigate the impact of alpha7 nAChR pharmacological modulation on mecamylamine-precipitated nicotine withdrawal behaviors in mice by using positive allosteric modulators (PAMs). | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 4 | Nicotine withdrawal signs were precipitated upon administration of the non-selective nAChR antagonist mecamylamine (3.5 mg/kg, i.p.). | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 5 | CONCLUSIONS: Taken together, our results suggest that modulation of the alpha7 nAChR can play important roles in mecamylamine-precipitated nicotine withdrawal behaviors in mice. | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 6 | These findings highlight a beneficial effect of using alpha7 nAChR PAMs in some aspects of precipitated nicotine withdrawal. | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |