Title : MEK inhibition leads to BRCA2 downregulation and sensitization to DNA damaging agents in pancreas and ovarian cancer models.

Pub. Date : 2018 Feb 20

PMID : 29545922






1 Functional Relationships(s)
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Protein Name
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1 MEK inhibition was sufficient to induce formation of gammaH2AX foci, suggesting that inhibition of this pathway would impair DNA repair. gammah2ax mitogen-activated protein kinase kinase 7 Homo sapiens