Title : Protective effect and molecular mechanism of liquiritin on oxybuprocaine-induced apoptosis of human corneal endothelial cells.

Pub. Date : 2018 Apr

PMID : 29545865






4 Functional Relationships(s)
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1 Investigation of molecular mechanism revealed that the pretreatment with liquiritin and pyrrolidinedithiocarbamic acid (PDTC) obviously blocked the expression of NF-kappaB p65 in nuclear protein increased by oxybuprocaine and the expression levels of total proteins, caspase-3 and Bax.Moreover, tumor necrosis factor-alpha (TNF-alpha) blocked the inhibitory effect of liquiritin on the expression of NF-kappaB p65 in nuclear protein and total proteins, caspase-3 and Bax, thus obstructing the protective effect of liquiritin on corneal epithelial cells. pyrrolidine dithiocarbamic acid nuclear factor kappa B subunit 1 Homo sapiens
2 Investigation of molecular mechanism revealed that the pretreatment with liquiritin and pyrrolidinedithiocarbamic acid (PDTC) obviously blocked the expression of NF-kappaB p65 in nuclear protein increased by oxybuprocaine and the expression levels of total proteins, caspase-3 and Bax.Moreover, tumor necrosis factor-alpha (TNF-alpha) blocked the inhibitory effect of liquiritin on the expression of NF-kappaB p65 in nuclear protein and total proteins, caspase-3 and Bax, thus obstructing the protective effect of liquiritin on corneal epithelial cells. pyrrolidine dithiocarbamic acid nuclear factor kappa B subunit 1 Homo sapiens
3 Investigation of molecular mechanism revealed that the pretreatment with liquiritin and pyrrolidinedithiocarbamic acid (PDTC) obviously blocked the expression of NF-kappaB p65 in nuclear protein increased by oxybuprocaine and the expression levels of total proteins, caspase-3 and Bax.Moreover, tumor necrosis factor-alpha (TNF-alpha) blocked the inhibitory effect of liquiritin on the expression of NF-kappaB p65 in nuclear protein and total proteins, caspase-3 and Bax, thus obstructing the protective effect of liquiritin on corneal epithelial cells. pyrrolidine dithiocarbamic acid nuclear factor kappa B subunit 1 Homo sapiens
4 Investigation of molecular mechanism revealed that the pretreatment with liquiritin and pyrrolidinedithiocarbamic acid (PDTC) obviously blocked the expression of NF-kappaB p65 in nuclear protein increased by oxybuprocaine and the expression levels of total proteins, caspase-3 and Bax.Moreover, tumor necrosis factor-alpha (TNF-alpha) blocked the inhibitory effect of liquiritin on the expression of NF-kappaB p65 in nuclear protein and total proteins, caspase-3 and Bax, thus obstructing the protective effect of liquiritin on corneal epithelial cells. pyrrolidine dithiocarbamic acid nuclear factor kappa B subunit 1 Homo sapiens