Title : MicroRNA-383 upregulation protects against propofol-induced hippocampal neuron apoptosis and cognitive impairment.

Pub. Date : 2018 Apr

PMID : 29545833






1 Functional Relationships(s)
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1 Propofol treatment significantly reduced the relative mRNA and protein expression of miR-383, induced neuron apoptosis, upregulated the Bax/Bcl-2 ratio, downregulated the relative mRNA and protein expression levels of postsynaptic density protein 95 and cAMP-response element binding protein, and inactivated the phosphoinositide 3-kinase/protein kinase B signaling pathway. Propofol discs large MAGUK scaffold protein 4 Rattus norvegicus