Protein Name discs large MAGUK scaffold protein 4
Organism Rattus norvegicus
Gene ID 29495
Gene Symbol

Dlg4

UniProt P31016 (DLG4_RAT)
Relationships Total Number of functionally related compound(s) : 230
Total Number of Articles : 303
Description

discs large MAGUK scaffold protein 4

Gene Summary

Enables several functions, including PDZ domain binding activity; enzyme binding activity; and signaling receptor binding activity. A structural constituent of postsynaptic density. Involved in several processes, including modulation of chemical synaptic transmission; positive regulation of cellular component organization; and postsynapse organization. Located in several cellular components, including dendrite; juxtaparanode region of axon; and postsynaptic density. Is active in glutamatergic synapse. Is anchored component of postsynaptic density membrane. Colocalizes with postsynaptic membrane. Biomarker of Parkinson's disease and temporal lobe epilepsy. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability. Orthologous to human DLG4 (discs large MAGUK scaffold protein 4). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • disks large homolog 4
  • PSD-95
  • SAP-90
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Properties