| Protein Name | discs large MAGUK scaffold protein 4 |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 29495 |
| Gene Symbol | Dlg4 |
| UniProt | P31016 (DLG4_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
230
Total Number of Articles : 303 |
Description |
discs large MAGUK scaffold protein 4 |
| Gene Summary |
Enables several functions, including PDZ domain binding activity; enzyme binding activity; and signaling receptor binding activity. A structural constituent of postsynaptic density. Involved in several processes, including modulation of chemical synaptic transmission; positive regulation of cellular component organization; and postsynapse organization. Located in several cellular components, including dendrite; juxtaparanode region of axon; and postsynaptic membrane. Part of voltage-gated potassium channel complex. Is active in glutamatergic synapse and postsynaptic density membrane. Biomarker of Parkinson's disease and temporal lobe epilepsy. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 62. Orthologous to human DLG4 (discs large MAGUK scaffold protein 4). [provided by Alliance of Genome Resources, Jun 2025] |
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| Properties | |